Ghostface Killah debuted on the opening verse of Bring da Ruckus, the first track from the Wu-Tang Clan's critically acclaimed debut, 1993's Enter the Wu-Tang (36 Chambers). In 1995, Ghostface played a significant role on (fellow Clan member) Raekwon's Only Built 4 Cuban Linx, and contributed songs to the soundtracks to Sunset Park and Don't Be A Menace To South Central While Drinking Your Juice In The Hood. His first solo LP was Ironman in 1996 (see 1996 in music), which was successful in hip hop circles and debuted at #2 on the pop charts. It had more of a pronounced soul influence (particularly 1970s soul) than previous Wu-Tang solo releases, and Ghostface's future albums would continue this stylistic trait.

Ghostface became well-known for both his uptempo, seemingly indecipherable stream-of-consciousness raps and, later in his career, for his very emotionally charged delivery (first seen on the Wu-Tang Clan track "Impossible"). His follow-up to Ironman was Supreme Clientele in 2000 (see 2000 in music), which was critically acclaimed by both mainstream critics and hip hop enthusiasts. "Cherchez LaGhost", a single off the album, became a minor club hit, and the sentimental "Child's Play" brought Ghostface numerous comparisons with Slick Rick.

Ghostface wasted little time in recording his next album, the heavily R&B-influenced Bulletproof Wallets which was released a year after Supreme Clientele. He had another minor club hit with "Flowers" (meaning rappers, people who "flow" lyrically, rather than a reference to horticulture) which featured guest vocals from fellow Wu-Tang members Method Man and Raekwon.

In April of 2004, The Pretty Toney Album was released on Def Jam; it featured collaborations with Missy Elliott and Jadakiss and was Ghostface's first (and so far, only) album to be credited to "Ghostface" rather than "Ghostface Killah". "Tush" and "Run", two singles taken from The Pretty Toney Album, achieved moderate success in the clubs and the charts. The album was named 9th Best Album of the Year on Pitchfork Media's end of the year list.[1] Ghostface also appeared on the track "On My Knees" by UK R&B group The 411 which became a hit in the UK and Australia, and released an album titled 718 with a group of his proteges, Theodore Unit. In November 2005, along with Trife Da God they released the joint project Put It On The Line. In 2006, Ghostface teamed up with underground favorite MF DOOM for an upcoming collaborative release entitled Swift and Changeable.

MF DOOM also produced several songs for Ghostface's latest album Fishscale, released under his original moniker "Ghostface Killah". The album debuted strongly, in the #4 position on the US Billboard 200 and at #2 on the R&B Charts[2]: the rapper's most auspicious chart showing since the heyday of the Wu-Tang Clan and the release of his solo debut. Ghostface also embarked on a limited-date tour of U.S. venues in support of the album, performing several of his concerts together with most members of the Wu-Tang Clan.

Ghostface is also due to release an action figure of himself in the near future.[3] Besides the collaborative effort with MF Doom a second Theodore Unit album tentativly titled 718: Stapelton to Somalia is rumored to be in the works.